If the final chapter of one piece shows the world 200 years from luffy's time, so by implication everyone would have died, would this resolve Yes

Or is a direct mention of the death of Donquixote Doflamingo in the mange needed for this to resolve Yes?

@AmmonLam specifically him confirmed dead before end of manga

if the 200 year timeskip happens and they all die... i might na them lol